EVALUATION OF PLATELETS AND SOME INFLAMMATION MARKERS OF PATIENTS WITH ACUTE MYELOID LEUKAEMIA IN A TERTIARY HOSPITAL IN UGANDA

  • Emmanuel Ifeanyi Obeagu Department of Medical Laboratory Science, Kampala International University, Uganda
  • Asiati Mbabazi Hospital Administrator, Kampala International University Teaching Hospital, Ishaka, Uganda.
  • Getrude Uzoma Obeagu Department of Nursing Science, Ebonyi State University, Abakaliki, Nigeria.
  • Emmanuel Muhimbura Department of Pathology and Laboratory Medicine, Kabale University, P.O. Box 317, Kabale, Ugnada
  • Matthew Chibunna Igwe Department of Medical Laboratory Science, Enugu State University of Science and Technology, Enugu State, Nigeria.
  • Tochi Andrew Owunna Maintenance, Babcock University Teaching Hospital, Ilishan Remo, Ogun State, Nigeria.
  • Chukwuma J. Okafor Department of Pathology and Biochemistry, State University of Zanzibar, Tanzania.
  • Shango Patience Emmanuel Jakheng Department of Microbiology, Kampala International University, Western Campus, Uganda.
Keywords: Acute myeloid leukaemia, Platelets, Inflammation markers, platelet indices

Abstract

The study was done to determine paltelets and some inflammation markers of patients with acute myeloid leukaemia in a tertiary hospital in Uganda. The study was done in Ishaka Uganda at Kampala International University Teaching Hospital, Ishaka, Uganda. The study adopted hospital based cross-sectional design where patients who attended the hospital with acute myeloid luekaemia (AML) were selected for the study on purposive sampling technique and the haematological variables evaluated with the apparently healthy individuals. The ages of the patients were below 25 years. A total of eighty (80) subjects comprising forty (40) acute myeloid patients and forty (40) apparently healthy subjects were recruited for the study using purposive sampling technique. The data were analysed using student t-test and present as mean ± standard deviation using SPSS version 20 and level of significance set at P<0.05. The results showed decrease in platelets (P=0.017), lymphocytes (P=0.047), neutrophils (P=0.009), NLR (P=0.005) and PLR (P=0.007), increase in PDW (P=0.007) and no significant difference in MPV (P=0.151) and PCT (P=0.057) of patients with acute myeloid leukaemia compared to the apparently health subjects respectively. The study revealed decrease in platelets, lymphocytes, neutrophils, NLR and PLR, increase in PDW and no significant difference in MPV  and PCT of patients with acute myeloid leukaemia.

Published
2022-10-01
How to Cite
Obeagu, E. I., Mbabazi, A., Obeagu, G. U., Muhimbura, E., Igwe, M. C., Owunna, T. A., Okafor, C. J., & Jakheng, S. P. E. (2022). EVALUATION OF PLATELETS AND SOME INFLAMMATION MARKERS OF PATIENTS WITH ACUTE MYELOID LEUKAEMIA IN A TERTIARY HOSPITAL IN UGANDA. Madonna University Journal of Medicine and Health Sciences ISSN: 2814-3035, 2(3), 78-84. Retrieved from https://journal.madonnauniversity.edu.ng/index.php/medicine/article/view/79
Issue
Vol 2 No 3 (2022): MUJMHS
Section
Articles
Copyright (c) 2022 Madonna University journal of Medicine and Health Sciences ISSN: 2814-3035

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