Histomorphological Effects of DaucursCarota Extract on Dispirin Induced Kidney Damage in Albino Rats

Abstract

This study was carried out to investigate the protective effect of extract against dispirin induced renal toxicity in albino rats. The histological effect of consumption of Daucurscarota root extract on the kidney of albino rats was carried out. The albino rats were divided into five groups. Each group consists of 5 albino rats. Group A serves as control while  group B, C, D and Ereceiveddispirin 80 mg/kg/day, 50mg, 100mgand 200mg/kg body weight per day of Daucurscarota extract respectively for a period of 28 days. Serum samples from each rat were subjected to biochemical analysis for kidney functions, while kidney biopsies were also investigated by histological examination. Dispirin significantly increased serum creatinine, urea, (p < 0.05). Moreover, dispirin induced significant histological and ultrastructural alterations in the renal tissues of the rats. The exposure to Daucurscarota extract did attenuate the dispirin-induced toxicity in renal tissues. These results suggest that Daucurscarota extracts have significant protective role against dispirin-induced renal toxicity.